Keeping in view the importance of Oxadiazole and Azetidinone compound, it is planned to synthesize a hybrid molecule comprising Oxadiazole and Azetidinone and were evaluated for Anticonvulsant activity. The Structures of all the synthesized compounds were elucidated on the basis of physical characterization (Melting point, TLC) and different Spectroscopy techniques (IR, 1H NMR and Mass spectroscopy). In the present study, anticonvulsant activities of Oxadiazole derivatives were evaluated by maximal electroshock method (MES) at 30, 100 and 200 mg/kg dose levels. Neurotoxicity of the compounds was also assessed at the same dose levels. Synthesized Compounds (SK0101- SK0109) gives anticonvulsant activity at different dose when compare with standard drug Phenytoin among that SK0101, SK0103, SK0105 gives better activity then others. Compounds SK0104, SK0106, SK0107, SK0109 show neurotoxicity at 100 mg and 200mg dose.
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